MATERNAL RESTRICTIVE DIETS DURING LACTATION IMPAIR GABAERGIC SIGNALING IN THE HYPOTHALAMUS AND MIDBRAIN IN MALE ADULT RATS

The aim of this work was to evaluate the behavioral parameters and GABAergic signalingin hypothalamus, midbrain medulla. Mothers litters were distributed into 3groups: Control (CO) fed with standard diet (20% protein), food restriction (FR) withstandard limited 50% daily consumption CO, low-protein (LP) withLP-diet (4% protein). Interventions carried out from 1st-14th, 14 th -21st day oflactation. Offspring both sexes evaluated until 120 days old by elevated plus maze(EPM) open field (OP) test. Male LP rats showed a decrease in closed arm (CO158±11.51 vs 105.5±9.63; s), an increase (CO 85.10±8.65 LP139.8±12.36; s) time, number entries 5.25±0.58 8.40±0.79;a.u.) compared CO. In OP, male crossings (CO51.94±4.29 71±3.41; a.u.) frequency 51.94±4.29 vs69.25±4.44; FR expression ofGABA B receptors 100±12.60 56.34 v 4.19; % control). midbrain, LPand GAD 100±11.22 47.59±6.21 74.18±8.82; %control) conclusion, maternal protein caloric duringlactation induces less anxious behavior increases exploratory activity males inadulthood, through modulation signaling.